He subsequently studied patients with thyrotoxicosis, anemia, polycythemia vera, carcinoma, and heart disease.
He examined the effects of physiologic and pharmacologic stresses and with his colleagues, and published 22 articles, chiefly in the Journal of Clinical Investigation.
Nuclear medicine’s history originates in the 1920’s, with its first diagnostic application occurring in the field of cardiology.
In 1927, Herman Blumgart used injectable solutions of radon gas and a Geiger tube to measure the “velocity of the circulation,” the time it took for the radioactivity to reach the heart, in normal volunteers.
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The application of positron emission tomography (PET) offers better spatial resolution and quantification than SPECT technology.
Global ventricular function and regional contraction of the ventricles could be studied, and quantitative measurements of stroke volumes, ejection fractions, and ventricular filling and emptying rates could be calculated.